This is a nootropic from the racetam family. Oxiracetam is highly recognized as a stimulant, which can produce great results in boosting motivation. For this nootropic, there are many anecdotes, even with its positive effects on motivation. Some users claim that the stimulating effects are similar to those of Adderall, while others say it’s only mildly stimulating. Owing to its water solubility and rather sweet taste, many users like to put Oxiracetam in their tea or coffee as a sweetener.
Uridine can effectively modulate the dopaminergic system, which means that it can improve the dopaminergic transmission in the brain. It can achieve this on its own, be increasing the density of the dopamine receptors, and enhancing the release of dopamine. Nonetheless, it also seems to decrease the dopaminergic activities of other substances. As such, it should only be taken if you don’t plan on using other dopaminergic supplements.
As an antidepressant nootropic, Tianeptine is perfect for people suffering from anxiety and depression. The supplement is also great in producing a mood lift and alleviating any depressive symptoms. For this reason, if low mood or depression is affecting your levels of motivation, Tianeptine can be very effective in boosting your motivation. Initially, it was thought to be an enhancer of serotonin reuptake, but it’s now known that it works by altering the glutamatergic activity in the brain.
This is one of the more potent supplements in the racetam family of nootropics. It has been used in Russia as a doping agent, and just like Oxiracetam, it’s thought to be a stimulant. What separates Phenylpiracetam from Oxiracetam is that it upregulates the D1, D2, and D3 dopamine receptors. These receptors are generally involved in motivation and reward. Moreover, in case it’s not producing increased motivation by itself, you can synergize Phenylpiracetam with other nootropics for motivation.
Selegiline is also known as Deprenyl, which is considered one of the best nootropic for motivation. As an irreversible MAO-B inhibitor, the drug is used to treat the Parkinson’s disease, which is a condition where the dopamine-producing neurons die causing a significant decrease in the amount of dopaminergic activity in the brain. Selegiline can be used as a subtle nootropic that can effectively enhance the effective dopaminergic nootropic. It’s quite stimulating on its own and does increase motivation in subtle manners.
Note that Selegiline will increase the levels of dopamine in the striatum that has an important role in motivation and reward functions. Combining modafinil, caffeine, and Selegiline can produce strong synergistic effects since all of these nootropics improve the dopaminergic activities in the brain. Keep in mind that you have to reduce the dosages of each of these nootropics, since too much dopamine, which could cause over-simulation and might cause restlessness.